The atypical chemokine receptor ACKR3 has recently been noted to work as an opioid scavenger with special damaging regulatory properties to various family members of opioid peptides.

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The study workforce described the receptor as an “opioid scavenger” on account of its capability to entice By natural means taking place opioids in advance of they could communicate with classical opioid receptors.

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In the current analyze, we noted the identification along with the characterization of a completely new atypical opioid receptor with distinctive damaging regulatory properties in direction of opioid peptides.1 Our final results showed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a wide-spectrum scavenger for opioid peptides with the enkephalin, dynorphin, and nociceptin family members, regulating their availability for classical opioid receptors.

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